Effects of supplemented Taohe Chengqi Decoction[inline-graphic not available: see fulltext] in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus

被引：0

作者：

Xiong Manqi ^{[1
]}

Lin Anzhong ^{[1
]}

Zhu Zhangzhi ^{[1
]}

Cai Wenjiu ^{[1
]}

Zheng Gaofei ^{[1
]}

Zhong Chunning ^{[1
]}

Chen Zhixi ^{[1
]}

Jia Keliang ^{[1
]}

Shen Suiting ^{[1
]}

He Min ^{[1
]}

机构：

[1] Guangzhou University of Traditional Chinese Medicine,First Affiliated Hospital

来源：

Chinese Journal of Integrated Traditional and Western Medicine | 1999年 / 5卷 / 1期

关键词：

supplemented Taohe Chengqi Decoction; non-insulin dependent diabetes mellitus; insulin resistance; insulin mediator; glucose metabolism; insulin sensitivity;

D O I：

10.1007/BF02934192

中图分类号：

学科分类号：

摘要：

Objective: To investigate the effect of supplemented Taohe Chengqi Decoction ([graphic not available: see fulltext], STHCQD) in treating non-insulin dependent diabetes mellitus (NIDDM).Methods: The model of rats with NIDDM was formed with injection of streptozotocin and fed on high calorie diet to study the effects of STHCQD on the release of insulin sensitivity.Results: (1) Fasting serum glucose, serum insulin, intake of food and water were significantly decreased (P < 0.05- 0.01) in STHCQD-treated diabetic rats as compared with untreated diabetic rats, while the insulin sensitivity was significantly increased (P < 0.05). (2) The liver cell membranes from STHCQD-treated diabetic rats released the quantity of insulin receptor which inhibited adenylate cyclase activity, but this effect was blunted in untreated diabetic rats (P < 0.05). (3) A significantly increased glucose oxidation in adipocyte of STHCQD-treated diabetic rats was found as compared with those of untreated diabetic rats (P < 0.05).Conclusions: STHCQD therapy increased sensitivity and responsiveness of target cells to insulin, i.e. it might decrease insulin resistance at receptor sites and post-receptor sites in rats with NIDDM, but could not reverse the insulin resistance.

引用

页码：54 / 58

页数：4

共 7 条

[1]

Lowry OH(1951)Protein measurement with the folin phenol reagent J Biol Chem 193 265-275

[2]

Rosebrough NJ(1970)Isolation of liver plasma membranes. Use of nucleotide pyrophosphatase and phosphodiesterase 1 as marker enzymes J Cell Biol 47 64-72

[3]

Farr Al(1982)Insulin binding and action on fat cells from young healthy females and males Am J Physiol 243 E158-167

[4]

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