Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis

被引：2

作者：

Kho, Sooyeon ^{[1
]}

Seung, Kwonjune J. ^{[1
,2
]}

Huerga, Helena ^{[3
]}

Bastard, Mathieu ^{[3
]}

Khan, Palwasha Y. ^{[4
,5
]}

Mitnick, Carole D. ^{[1
,2
,6
]}

Rich, Michael L. ^{[1
,2
]}

Islam, Shirajul ^{[7
]}

Zhizhilashvili, Dali ^{[8
]}

Yeghiazaryan, Lusine ^{[9
]}

Nikolenko, Elena Nikolaevna ^{[10
]}

Zarli, Khin ^{[11
]}

Adnan, Sana ^{[12
]}

Salahuddin, Naseem ^{[12
]}

Ahmed, Saman ^{[13
]}

Vargas, Zully Haydee Ruiz ^{[14
]}

Bekele, Amsalu ^{[15
,16
]}

Shaimerdenova, Aiman ^{[17
]}

Tamirat, Meseret ^{[18
]}

Gelin, Alain ^{[19
]}

Vilbrun, Stalz Charles ^{[20
]}

Hewison, Catherine ^{[21
]}

Khan, Uzma ^{[5
]}

Franke, Molly ^{[2
,6
]}

机构：

[1] Brigham & Womens Hosp, Div Global Hlth Equ, Boston, MA USA

[2] Partners Hlth, 800 Boylston St,Suite 300, Boston, MA 02199 USA

[3] Epicentre, 14-34 Ave Jean Jaures, Paris, France

[4] London Sch Hyg & Trop Med, Dept Clin Res, London, England

[5] Interact Res & Dev Global, Singapore, Singapore

[6] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA 02115 USA

[7] Interact Res & Dev, Dhaka, Bangladesh

[8] Medecins Sans Frontieres, Tbilisi, Georgia

[9] Natl Ctr Pulmonol, Yerevan, Armenia

[10] Republican Res & Pract Ctr Pulmonol & TB, Minsk, BELARUS

[11] Medecins Sans Frontieres, Yangon, Myanmar

[12] Indus Hosp & Hlth Network, Karachi, Pakistan

[13] Interact Res & Dev, Karachi, Pakistan

[14] Maria Auxiliadora Hosp, San Juan De Miraflores, Peru

[15] Tikur Anbessa Specialized Hosp, Dept Internal Med, Addis Ababa, Ethiopia

[16] Addis Ababa Univ, Coll Hlth Sci, Addis Ababa, Ethiopia

[17] Karaganda Reg Ctr Phthisiopulmonol, Karaganda, Kazakhstan

[18] Partners Hlth, Maseru, Lesotho

[19] Zanmi Lasante, Port Au Prince, Haiti

[20] Haitian Grp Study Kaposis Sarcoma & Opportunist In, Port Au Prince, Haiti

[21] Medecins Sans Frontieres, Dept Med, Paris, France

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

关键词：

TREATMENT OUTCOMES; MYCOBACTERIUM-TUBERCULOSIS; POOR OUTCOMES; CONVERSION; DEFINITIONS; PREDICTORS; INFECTION; REGIMENS;

D O I：

10.1038/s41467-024-48077-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sputum culture reversion after conversion is an indicator of tuberculosis (TB) treatment failure. We analyze data from the endTB multi-country prospective observational cohort (NCT03259269) to estimate the frequency (primary endpoint) among individuals receiving a longer (18-to-20 month) regimen for multidrug- or rifampicin-resistant (MDR/RR) TB who experienced culture conversion. We also conduct Cox proportional hazard regression analyses to identify factors associated with reversion, including comorbidities, previous treatment, cavitary disease at conversion, low body mass index (BMI) at conversion, time to conversion, and number of likely-effective drugs. Of 1,286 patients, 54 (4.2%) experienced reversion, a median of 173 days (97-306) after conversion. Cavitary disease, BMI < 18.5, hepatitis C, prior treatment with second-line drugs, and longer time to initial culture conversion were positively associated with reversion. Reversion was uncommon. Those with cavitary disease, low BMI, hepatitis C, prior treatment with second-line drugs, and in whom culture conversion is delayed may benefit from close monitoring following conversion.

引用

页数：7

共 34 条

[1]

[Anonymous], 2019, WHO consolidated guidelines on drug-resistant tuberculosis treatment

[2]

[Anonymous], 2014, Definitions and reporting framework for tuberculosis - 2013 revision

[3]

[Anonymous], 2022, WHO consolidated guidelines on tuberculosis

[4]

Arnold A, 2017, J INFECTION, V74, P260, DOI [10.1016/j.jinf.201, 10.1016/j.jinf.2016.12.005]

[5] Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline [J].

Diacon, Andreas H. ;

Pym, Alexander ;

Grobusch, Martin P. ;

de los Rios, Jorge M. ;

Gotuzzo, Eduardo ;

Vasilyeva, Irina ;

Leimane, Vaira ;

Andries, Koen ;

Bakare, Nyasha ;

De Marez, Tine ;

Haxaire-Theeuwes, Myriam ;

Lounis, Nacer ;

Meyvisch, Paul ;

De Paepe, Els ;

van Heeswijk, Rolf P. G. ;

Dannemann, Brian .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (08) :723-732

[6] Culture Conversion in Patients Treated with Bedaquiline and/or Delamanid A Prospective Multicountry Study [J].

Franke, Molly F. ;

Khan, Palwasha ;

Hewison, Cathy ;

Khan, Uzma ;

Huerga, Helena ;

Seung, Kwonjune J. ;

Rich, Michael L. ;

Zarli, Khin ;

Samieva, Nazgul ;

Oyewusi, Lawrence ;

Nair, Parvati ;

Mudassar, Mishaz ;

Melikyan, Nara ;

Lenggogeni, Putri ;

Lecca, Leonid ;

Kumsa, Andargachew ;

Khan, Munira ;

Islam, Shirajul ;

Hussein, Kerow ;

Docteur, Wisny ;

Chumburidze, Nino ;

Berikova, Elmira ;

Atshemyan, Hakob ;

Atwood, Sidney ;

Alam, Manzurul ;

Ahmed, Saman ;

Bastard, Mathieu ;

Mitnick, Carole D. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (01) :111-119

[7] Aggressive Regimens for Multidrug-Resistant Tuberculosis Reduce Recurrence [J].

Franke, Molly F. ;

Appleton, Sasha C. ;

Mitnick, Carole D. ;

Furin, Jennifer J. ;

Bayona, Jaime ;

Chalco, Katiuska ;

Shin, Sonya ;

Murray, Megan ;

Becerra, Mercedes C. .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (06) :770-776

[8] Bacteriologic monitoring of multidrug-resistant tuberculosis patients in five DOTS-Plus pilot projects [J].

Gammino, V. M. ;

Taylor, A. B. ;

Rich, M. L. ;

Bayona, J. ;

Becerra, M. C. ;

Bonilla, C. ;

Gelmanova, I. ;

Hollo, V. ;

Jaramillo, E. ;

Keshavjee, S. ;

Leimane, V. ;

Mitnick, C. D. ;

Quelapio, M. I. D. ;

Riektsina, V. ;

Tupasi, T. E. ;

Wells, C. D. ;

Zignol, M. ;

Cegielski, P. J. .

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2011, 15 (10) :1315-1322

[9]

Günther G, 2016, NEW ENGL J MED, V375, P1103, DOI 10.1056/NEJMc1603274

[10] Safety of Treatment Regimens Containing Bedaquiline and Delamanid in the endTB Cohort [J].

Hewison, Catherine ;

Khan, Uzma ;

Bastard, Mathieu ;

Lachenal, Nathalie ;

Coutisson, Sylvine ;

Osso, Elna ;

Ahmed, Saman ;

Khan, Palwasha ;

Franke, Molly F. ;

Rich, Michael L. ;

Varaine, Francis ;

Melikyan, Nara ;

Seung, Kwonjune J. ;

Adenov, Malik ;

Adnan, Sana ;

Danielyan, Narine ;

Islam, Shirajul ;

Janmohamed, Aleeza ;

Karakozian, Hayk ;

Kimenye, Maureen Kamene ;

Kirakosyan, Ohanna ;

Kholikulov, Begimkul ;

Krisnanda, Aga ;

Kumsa, Andargachew ;

Leblanc, Garmaly ;

Lecca, Leonid ;

Nkuebe, Mpiti ;

Mamsa, Shahid ;

Padayachee, Shrivani ;

Thit, Phone ;

Mitnick, Carole D. ;

Huerga, Helena .

CLINICAL INFECTIOUS DISEASES, 2022, 75 (06) :1006-1013

← 1 2 3 4 →