Regulation of GSK3 isoforms by phosphatases PP1 and PP2A

被引：0
作者：
Félix Hernández
Elena Langa
Raquel Cuadros
Jesús Avila
Nieves Villanueva
机构：
[1] Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM),
[2] CIBERNED,undefined
[3] Centro Nacional de Microbiología,undefined
[4] Instituto de Salud Carlos III,undefined
来源：
Molecular and Cellular Biochemistry | 2010年 / 344卷
关键词：
GSK-3; PP1; PP2A; Okadaic acid; Lithium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Dephosphorylation of phospho GSK3 isoforms, from COS-7 cells, was determined in vitro and in cultured cells in the absence or the presence of okadaic acid and lithium. Our results indicate a preferential dephosphorylation of phospho GSK3α by PP2A phosphatase, whereas dephosphorylation of phospho GSK3β mainly takes place by PP1 phosphatase.
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页码：211 / 215
页数：4
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