4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

Xu J(2002)Sigma receptors: recent advances and new clinical potentials Bioorg Med Chem Lett 12 497-5372

Wan BL(2011)The hallucinogen N, N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator J Med Chem 54 5362-518

Zuckerman A(2004)Novel potent ChemBioChem 5 508-3862

Seth P(1996)-methyl-D-aspartate (NMDA) receptor antagonists or σ1 receptor ligands Based on properly substituted 1,4-dioxane ring J Org Chem 61 3849-566

Fei YJ(2014)One-pot synthesis and sigma receptor binding studies of novel spirocyclic-2,6-diketopiperazine derivatives Med Res Rev 34 532-1560

Li HW(1998)Is a nitrogen atom an important pharmacophoric element in sigma ligand binding? J Med Chem 41 1557-214

Huang W(2004)Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the “deconstruction-reconstruction-elaboration” approach Breast Cancer Res Treat 87 205-448

Leibach FH(2002)Sigma-1 ligands: Tic-hydantoin as a key pharmacophore J Med Chem 45 438-126

Prasad PD(1993)GRIND-derived pharmacophore model for a series of α-tropanyl derivative ligands of the sigma-2 receptor Mol Neuropharmacol 3 117-3311

Li HW(2004)N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents Bioorg Med Chem 12 3299-54

Xu J(2002)Sigma receptors: recent advances and new clinical potentials Bioorg Med Chem Lett 12 497-5372

Wan BL(2011)The hallucinogen N, N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator J Med Chem 54 5362-518

Zuckerman A(2004)Novel potent ChemBioChem 5 508-3862

Seth P(1996)-methyl-D-aspartate (NMDA) receptor antagonists or σ1 receptor ligands Based on properly substituted 1,4-dioxane ring J Org Chem 61 3849-566

Fei YJ(2014)One-pot synthesis and sigma receptor binding studies of novel spirocyclic-2,6-diketopiperazine derivatives Med Res Rev 34 532-1560

Li HW(1998)Is a nitrogen atom an important pharmacophoric element in sigma ligand binding? J Med Chem 41 1557-214

Huang W(2004)Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the “deconstruction-reconstruction-elaboration” approach Breast Cancer Res Treat 87 205-448

Leibach FH(2002)Sigma-1 ligands: Tic-hydantoin as a key pharmacophore J Med Chem 45 438-126

Prasad PD(1993)GRIND-derived pharmacophore model for a series of α-tropanyl derivative ligands of the sigma-2 receptor Mol Neuropharmacol 3 117-3311

Li HW(2004)N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents Bioorg Med Chem 12 3299-54