SARS-CoV-2 variants, immune escape, and countermeasures

被引：0
作者：
Yi Zhang
Haocheng Zhang
Wenhong Zhang
机构：
[1] Fudan University,Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital
[2] Fudan University,State Key Laboratory of Genetic Engineering and Institute of Biostatistics, School of Life Sciences
来源：
Frontiers of Medicine | 2022年 / 16卷
关键词：
SARS-CoV-2; COVID-19; vaccine; immune escape; breakthrough; prevention;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Coronavirus disease 2019 (COVID-19) has become a global pandemic disease. SARS-CoV-2 variants have aroused great concern and are expected to continue spreading. Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully established, indicating that populations remain susceptible to infection. In this review, we summarize the literature on variants of concern and focus on the changes in their transmissibility, pathogenicity, and resistance to the immunity constructed by current vaccines. Furthermore, we analyzed relationships between variants and breakthrough infections, as well as the paradigm of new variants in countries with high vaccination rates. Terminating transmission, continuing to strengthen variant surveillance, and combining nonpharmaceutical intervention measures and vaccines are necessary to control these variants.
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页码：196 / 207
页数：11
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