Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension

被引：0

作者：

Hsin-Hung Chen

Pei-Wen Cheng

Wen-Yu Ho

Pei-Jung Lu

Chi-Cheng Lai

Yang-Ming Tseng

Hua-Chang Fang

Gwo-Ching Sun

Michael Hsiao

Chun-Peng Liu

Ching-Jiunn Tseng

机构：

[1] Kaohsiung Veterans General Hospital,Department of Medical Education and Research

[2] Kaohsiung,Division of General Internal Medicine, Department of Internal Medicine

[3] Taiwan,Department of Pathology and Laboratory Medicine

[4] Institute of Clinical Medicine,Division of Nephrology

[5] National Yang-Ming University,Department of Anesthesiology

[6] Yuh-Ing Junior College of Health Care & Management,Department of Administration

[7] Kaohsiung Medical University Hospital,Department of Medcine

[8] Kaohsiung Medical University,Department of Medical Research

[9] Kaohsiung,undefined

[10] Taiwan,undefined

[11] Graduate Institute of Clinical Medicine,undefined

[12] National Cheng-Kung University,undefined

[13] Cardiovascular Center,undefined

[14] Kaohsiung Veterans General Hospital,undefined

[15] Kaohsiung,undefined

[16] Taiwan,undefined

[17] Kaohsiung Veterans General Hospital,undefined

[18] Kaohsiung,undefined

[19] Taiwan,undefined

[20] Kaohsiung Veterans General Hospital,undefined

[21] Kaohsiung,undefined

[22] Taiwan,undefined

[23] Kaohsiung Medical University Hospital,undefined

[24] Kaohsiung Medical University,undefined

[25] Kaohsiung,undefined

[26] Taiwan,undefined

[27] Genomics Research Center,undefined

[28] Academia Sinica,undefined

[29] Kaohsiung Veterans General Hospital,undefined

[30] Section of Cardiology,undefined

[31] Tri-Service General Hospital,undefined

[32] National Defense Medical Center,undefined

[33] China Medical University Hospital,undefined

[34] China Medical University,undefined

[35] Institute of Biomedical Sciences,undefined

[36] National Sun Yat-sen University,undefined

来源：

Scientific Reports | / 6卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Hypertensive rats with chronic kidney disease (CKD) exhibit enhanced gamma-aminobutyric acid (GABA)B receptor function and regulation within the nucleus tractus solitarii (NTS). For CKD with hypertension, renal denervation (RD) interrupts the afferent renal sympathetic nerves, which are connecting to the NTS. The objective of the present study was to investigate how RD improves CKD-induced hypertension. Rats underwent 5/6 nephrectomy for 8 weeks, which induced CKD and hypertension. RD was induced by applying phenol to surround the renal artery in CKD. RD improved blood pressure (BP) by lowering sympathetic nerve activity and markedly restored the baroreflex response in CKD. The GABAB receptor expression was increased in the NTS of CKD; moreover, the central GABA levels were reduced in the cerebrospinal fluid, and the peripheral GABA levels were increased in the serum. RD restored the glutamic acid decarboxylase activity in the NTS in CKD, similar to the effect observed for central treatment with baclofen, and the systemic administration of gabapentin reduced BP. RD slightly improved renal function and cardiac load in CKD. RD may improve CKD-induced hypertension by modulating the baroreflex response, improving GABA system dysfunction and preventing the development and reducing the severity of cardiorenal syndrome type 4 in CKD rats.

引用