SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age

被引：0
作者：
Raphael N. Vuille-dit-Bille
Kenneth W. Liechty
François Verrey
Laura C. Guglielmetti
机构：
[1] University Children’s Hospital of Basel,Department of Pediatric Surgery
[2] University of Zurich,Institute of Physiology
[3] University Children’s Hospital of Colorado,Department of Pediatric Surgery
[4] University of Zurich,Swiss National Centre of Competence in Research Kidney.CH
[5] Cantonal Hospital of Winterthur,Department of Visceral and Thoracic Surgery
来源：
Amino Acids | 2020年 / 52卷
关键词：
ACE2; COVID-19; SARS-CoV-2; Age;
D O I：
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中图分类号：
学科分类号：
摘要：
Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients’ age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman’s r = 0.317, p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.
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页码：1063 / 1065
页数：2
相关论文
共 38 条
[1]  
Camargo SM(2009)Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations Gastroenterology 136 872-882
[2]  
D’Amico F(2020)Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention, and management Clin Gastroenterol Hepatol 158 1518-1519
[3]  
Baumgart DC(2020)COVID-19: gastrointestinal manifestations and potential fecal-oral transmission Gastroenterology 203 631-637
[4]  
Danese S(2004)Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis J Pathol 487 477-481
[5]  
Peyrin-Biroulet L(2012)ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation Nature 382 929-936
[6]  
Gu J(2020)SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Cell 69 1002-1009
[7]  
Han B(2020)First case of 2019 novel coronavirus in the United States N Engl J Med 315 G887-G895
[8]  
Wang J(2020)Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Gut 69 611-618
[9]  
Hamming I(2018)Intestinal IMINO transporter SIT1 is not expressed in human newborns Am J Physiol Gastrointest Liver Physiol 51 843-851
[10]  
Hashimoto T(2019)Mucosal monosaccharide transporter expression in newborns with jejunoileal atresia and along the adult intestine J Pediatr Gastroenterol Nutr 458 53-60
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