Undifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patients

被引：0
作者：
C. C. Vaz
M. Couto
D. Medeiros
L. Miranda
J. Costa
P. Nero
R. Barros
M. J. Santos
E. Sousa
A. Barcelos
L. Inês
机构：
[1] Coimbra University Hospital,Department of Rheumatology
[2] Coimbra University,Institute of Physiology, Faculty of Medicine
[3] Portuguese Institute of Rheumatology,Department of Rheumatology
[4] Alto Minho Hospital Centre,Department of Rheumatology
[5] Egas Moniz Hospital,Department of Rheumatology
[6] Garcia de Orta Hospital,Department of Rheumatology
[7] Santa Maria Hospital,Rheumatology Unit
[8] Infante D. Pedro Hospital,Faculty of Health Sciences
[9] University of Beira Interior,undefined
来源：
Clinical Rheumatology | 2009年 / 28卷
关键词：
Classification criteria; Connective tissue diseases; Systemic lupus erythematosus; Undifferentiated connective tissue diseases;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The purpose of this study was to characterize the clinical and serological features of a large cohort of patients with antinuclear antibody (ANA) positive undifferentiated connective tissue disease (UCTD). Consecutive patients with UCTD, followed up at the Rheumatology Clinic of the participating centers, were included. Data from these patients were obtained by clinical evaluation and chart review. All patients were diagnosed as having UCTD on basis of the following criteria: positive ANA plus at least one clinical feature of connective tissue disease, but not fulfilling classification criteria for any differentiated connective tissue disease. One hundred eighty-four patients were studied (female patients—94.5%; mean age at time of evaluation—47 years). The most prevalent manifestations were arthralgia (66%), arthritis (32%), Raynaud’s phenomenon (30%), sicca symptoms (30%), and leukopenia (19%). The prevalence of ANA was 100%, anti-SSA 20%, anti-dsDNA 14%, and anti-SSB 7%. Patients with anti-dsDNA/anti-Sm, anticentromere/anti-Scl70, or anti-SSA/anti-SSB antibodies more frequently presented a set of manifestations close to systemic lupus erythematosus (SLE), systemic sclerosis, or Sjögren syndrome, respectively. We analyze a large cohort of UCTD. Seventy-two percent of these UCTD patients present lupus-, scleroderma-, or Sjögren-like features but do not fulfill classification criteria and mostly present a mild disease.
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页码：915 / 921
页数：6
相关论文
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