Simvastatin suppresses homocysteine-induced apoptosis in endothelial cells: roles of caspase-3, cIAP-1 and cIAP-2

被引:0
作者
Zhihong Xu
Guoping Lu
Fang Wu
机构
[1] Ruijin Hospital,Department of Geriatrics
[2] Shanghai Jiaotong University,Department of Cardiology
[3] Ruijin Hospital,undefined
[4] Shanghai Jiaotong University,undefined
来源
Hypertension Research | 2009年 / 32卷
关键词
homocysteine; simvastatin; apoptosis; caspase; cIAP;
D O I
暂无
中图分类号
学科分类号
摘要
The present study addresses how homocysteine (Hcy) induces endothelial apoptosis and how simvastatin antagonizes these pro-apoptotic effects of Hcy.
引用
收藏
页码:375 / 380
页数:5
相关论文
共 94 条
[1]  
Au-Yeung KK(2004)Hyperhomocysteinemia activates nuclear factor-kB in endothelial cells via oxidative stress Circ Res 94 28-36
[2]  
Woo CW(1999)Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects Arterioscler Thromb Vasc Biol 19 2922-2927
[3]  
Sung FL(1997)The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases EMBO J 16 6914-6925
[4]  
Yip JC(1992)A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes Anal Biochem 204 351-356
[5]  
Siow YL(1999)Folate deficiency induces a cell cycle-specific apoptosis in HepG2 cells J Nutr 129 25-31
[6]  
O K(2002)Invasive pulmonary aspergillosis: identification of risk factors Scand J Infect Dis 34 819-822
[7]  
Chambers JC(2002)Cellular and molecular mechanism of cardiovascular disease resulting from hyperhomocysteinemia Sheng Li Ke Xue Jin Zhan 33 335-338
[8]  
Obeid OA(1996)Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes J Biol Chem 271 29659-29665
[9]  
Kooner JS(2004)p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells Apoptosis 9 211-221
[10]  
Roy N(2005)Targeting of X-linked inhibitor of apoptosis protein or survivin by short interfering RNAs sensitize hepatoma cells to TNF-related apoptosis-inducing ligand- and chemotherapeutic agent-induced cell death Oncol Rep 14 1311-1316