Recombinant factor VIIa: use in fatal post partum hemorrhage — Indian experience case series and review of literature

被引:0
作者
Shailesh R. Singi
Evita Fernandez
Sunil T. Pandya
H. R. Badrinath
机构
[1] CARE Hospitals,
[2] Fernandez Hospital,undefined
[3] Fernandez Hospital,undefined
[4] Novo Nordisk India,undefined
来源
Indian Journal of Hematology and Blood Transfusion | 2009年 / 25卷
关键词
PPH; Hemorrhage; rFVIIa; Coagulation; Bleeding; NICE registry; NovoSeven;
D O I
暂无
中图分类号
学科分类号
摘要
Postpartum hemorrhage is leading cause of maternal mortality and still remains a challenging condition to treat and hysterectomy may be required to control the bleeding once medical interventions fail. These strategies are not always successful and a direct approach in activating the coagulation system can be more effective and life saving. We describe here the mechanism of action of rFVIIa, review of literature and its use in 10 cases with different causes for PPH with good response.
引用
收藏
页码:1 / 5
页数:4
相关论文
共 51 条
[1]  
Mousa H.A.(2001)Major Post Partum Hemorrhage Curr Opin Obstet Gynecol 13 595-603
[2]  
Walkinshaw S.(1999)Pregnancy-related mortality in the united stats due to hemorrhage: 1979–1992 Obstet. Gynecol 94 721-1094
[3]  
Chichakli L.O.(2001)Incidence and predictors of severe obstetric morbidity: case-control study Brit Med J 322 1089-8
[4]  
Atrash H.K.(2001)Massive obstetric hemorrhage Bailieres Best Pract Res Clin Obstet-Gynecol 14 1-4
[5]  
Mackay A.P.(2004)Management recommendations for postpartum hemorrhage Arch Perinat Med 10 1-3864
[6]  
Musani A.S.(2004)The use of rFVIIa in the treatment of bleeding disorders Blood 104 3858-439
[7]  
Berg B.J.(1999)Treatment of traumatic bleeding with recombinant factor VIIa Lancet 354 1879-85
[8]  
Waterstone M.(2001)Recombinant activated factor VIIa for adjunctive hemorrhage control in trauma J Trauma 51 431-99
[9]  
Bewley S.(2006)Mechanism of action of Factor VIIa in the treatment of coagulopathies In Seminars in thrombosis and hemostasis 32 77-595
[10]  
Wolfe C.(2006)A universal haemostatic agent? Editorial Ann Card Anaesth 9 97-933