The Role of Excitatory Amino Acid Transporters in Cerebral Ischemia

被引：0
|
作者：
Xiao-dong Chao
Fei Fei
Zhou Fei
机构：
[1] Fourth Military Medical University,Department of Neurosurgery, Xi Jing Hospital
[2] Fourth Military Medical University,Department of Cell Biology/Cell Engineering Research Centre, Cancer Biology of State Key Laboratory and State Key Discipline of Cell Biology
来源：
Neurochemical Research | 2010年 / 35卷
关键词：
EAAT2; Cerebral ischemia; Glutamate (Glu); Excitatory amino acid transporters (EAATs);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glutamate is an excitatory neurotransmitter that plays a major role in the pathogenesis of ischemia brain injury. The regulation of glutamate neurotransmission is carried out by excitatory amino acid transporters (EAATs) that act through reuptake of glutamate into cells. EAATs may also release glutamate into the extracellular space in a calcium-independent manner during ischemia and dysfunction of EAATs is specifically implicated in the pathology of cerebral ischemia. Recent studies show that up-regulation of EAAT2 provides neuroprotection during ischemic insult. This review summarizes current knowledge regarding the role of EAATs in cerebral ischemia.
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页码：1224 / 1230
页数：6
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