The inhibition of NF-kB activation decreases the resistance of acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates

被引：0
|
作者：
Fadeev R.S. [1 ,2 ]
Solovieva M.E. [1 ]
Slyadovskiy D.A. [1 ,2 ]
Zakharov S.G. [3 ]
Fadeeva I.S. [1 ]
Senotov A.S. [1 ]
Golenkov A.K. [3 ]
Akatov V.S. [1 ,2 ]
机构：
[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast
[2] Pushchino State Natural Science Institute, pr. Nauki 5, Pushchino, Moscow oblast
[3] Vladimirsky Moscow Regional Research Clinical Institute, ul. Shchepkina 61/2, Moscow
来源：
Biophysics | 2015年 / 60卷 / 6期
基金：
俄罗斯基础研究基金会;
关键词：
acute myeloid leukemia; drug resistance; izTRAIL recombinant protein; multicellular aggregates;
D O I：
10.1134/S0006350915060056
中图分类号：
学科分类号：
摘要：
The suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates was studied using small molecular inhibitors of the activation of the transcription factor NF-kB, viz., NF-kB Activation Inhibitor IV and JSH-23 at nontoxic concentrations. NF-kB Activation Inhibitor IV and JSH-23 decreases the resistance of acute myeloid leukemia cells in multicellular aggregates to the cytotoxic action of the izTRAIL recombinant protein. It has been shown that the use of these inhibitors decreased the phosphorylation of RelA (p65) as a major marker of the activation of the NF-kB transcription factor. The potential causes of the increased resistance of acute myeloid leukemia cells to TRAIL-induced apoptosis in multicelluar aggregates are discussed. © 2015, Pleiades Publishing, Inc.
引用
收藏
页码：953 / 956
页数：3
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