Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview

被引:0
作者
Doreen Manuela Floss
Dieter Falkenburg
Udo Conrad
机构
[1] Leibniz Institute of Plant Genetics and Crop Plant Research (IPK),
[2] Novoplant GmbH,undefined
来源
Transgenic Research | 2007年 / 16卷
关键词
Molecular pharming; Plant-based vaccines; Therapeutic antibodies; Transgenic plants; Veterinary medicine;
D O I
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中图分类号
学科分类号
摘要
During the past two decades, antibodies, antibody derivatives and vaccines have been developed for therapeutic and diagnostic applications in human and veterinary medicine. Numerous species of dicot and monocot plants have been genetically modified to produce antibodies or vaccines, and a number of diverse transformation methods and strategies to enhance the accumulation of the pharmaceutical proteins are now available. Veterinary applications are the specific focus of this article, in particular for pathogenic viruses, bacteria and eukaryotic parasites. We focus on the advantages and remaining challenges of plant-based therapeutic proteins for veterinary applications with emphasis on expression platforms, technologies and economic considerations.
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页码:315 / 332
页数:17
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