The role of TGF-beta signaling in dendritic cell tolerance

被引：0
作者：
Grace E. Esebanmen
William H. R. Langridge
机构：
[1] Loma Linda University School of Medicine,Department of Earth and Biological Sciences
[2] Loma Linda University School of Medicine,Center for Health Disparities and Molecular Medicine
[3] Loma Linda University School of Medicine,Division of Biochemistry, Department of Basic Sciences
来源：
Immunologic Research | 2017年 / 65卷
关键词：
TGF-β signaling; Dendritic cells; T cells; Immunological tolerance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant isoform expressed in immune cells. TGF-β1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs). Based on the importance of DCs in regulation of the innate and adaptive arms of the immune system, in this review we explore the regulatory functions of TGF-β required for establishment and maintenance of DC-mediated immune tolerance.
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页码：987 / 994
页数：7
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