True hyponatremia secondary to intravenous immunoglobulin

被引：31

作者：

Nguyen M.K. ^{[1
]}

Rastogi A. ^{[1
]}

Kurtz I. ^{[1
]}

机构：

[1] Division of Nephrology, David Geffen School of Medicine at UCLA, Factor Building, Los Angeles, CA 90095

来源：

Clinical and Experimental Nephrology | 2006年 / 10卷 / 2期

关键词：

Hyponatremia; Intravenous immunoglobulin; Pseudohyponatremia; Sucrose;

D O I：

10.1007/s10157-006-0416-9

中图分类号：

学科分类号：

摘要：

Hyponatremia is characterized as either "true hyponatremia," which represents a decrease in the Na+ concentration in the water phase of plasma, or "pseudohyponatremia," which is due to an increased percentage of protein or lipid in plasma, with a normal plasma water Na + concentration ([Na+]). Pseudohyponatremia is a known complication of intravenous immunoglobulin (IVIG). Because IVIG has been reported to result in post-infusional hyperproteinemia, IVIG-induced hyponatremia has been attributed to pseudohyponatremia. In this case report, we demonstrate that IVIG therapy can result in true hyponatremia, resulting from sucrose-induced translocation of water from the intracellular compartment (ICF) to the extracellular compartment (ECF), as well as the infusion of a large volume of dilute fluid, in patients with an underlying defect in urinary free water excretion. © Japanese Society of Nephrology 2006.

引用

页码：124 / 126

页数：2

共 14 条

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[14] Zweens J., Frankena H., Sucrose as an indicator for the measurement of the extracellular fluid volume in man, Proceedings of the 21st Dutch Federation Meeting, (1980)

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