Changes of E-cadherin and β-catenin in Human and Mouse Intestinal Tumours

被引：0
作者：
E. Šloncová
P. Frič
D. Kučerová
Z. Lojda
Z. Tuháčková
V. Sovová
机构：
[1] Academy of Sciences of the Czech Republic,Institute of Molecular Genetics
[2] Central Military Hospital,Postgraduate Institute of Medicine
[3] Charles University 1st Faculty of Medicine,Laboratory of Histochemistry
[4] Academy of Sciences of the Czech Republic,Institute of Molecular Genetics
来源：
The Histochemical Journal | 2001年 / 33卷
关键词：
Epithelial Cell; Colorectal Cancer; Cell Adhesion; Immunohistochemical Analysis; Intestinal Mucosa;
D O I：
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中图分类号：
学科分类号：
摘要：
An immunohistochemical analysis of E-cadherin and β-catenin was performed in human colorectal cancer as well as in surrounding normal intestinal tissue. We also analysed the expression of these two cell adhesion proteins in transgenic Apc1638N mice as a model of human familial adenometous polyposis syndrome. In the normal intestinal mucosa of both species, E-cadherin and β-catenin were localized along the lateral plasma membrances of epithelial cells. In intestinal tumour cells, however, they were also present in the cytoplasm. The expression of both proteins was reduced in human and mouse tumours. The pattern of their distribution was frequently heterogenous with strongly positive cells in a mosaic of negative ones. Further, E-cadherin and β-catenin expression did not correlate to the Duke's staging of tumours and therefore neither can be used as prognostic criteria.
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页码：13 / 17
页数：4
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