Molecular and Genetic Aspects of Odontogenic Lesions

被引：13
作者：
Bilodeau E.A. [1 ]
Prasad J.L. [1 ]
Alawi F. [2 ]
Seethala R.R. [3 ]
机构：
[1] Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, 15261, PA
[2] Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA
[3] Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
来源：
Head and Neck Pathology | 2014年 / 8卷 / 4期
关键词：
BRAF; EWSR1; Molecular pathology; Mutation; Odontogenic tumors; PTCH; Translocation;
D O I：
10.1007/s12105-014-0588-7
中图分类号：
学科分类号：
摘要：
In this article we outline the molecular findings of select odontogenic tumors. In each section, we briefly review selected the clinicoradiographic, histologic, immunologic features, focusing on the molecular findings and their applications in practice. The understanding of molecular pathobiology at various other organ sites has developed quite rapidly in recent years, however much remains unknown about the genetic profile of odontogenic tumors. Improved understanding of mutations in odontogenic tumors may clarify classification schema and elucidate targets for novel therapies. Molecular testing will no doubt improve our understanding of odontogenic tumor pathogenesis and will likely be, someday, an important component of routine clinical practice and its role will only increase in the coming years. © 2014, Springer Science+Business Media New York.
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收藏
页码：400 / 410
页数：10
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