Chemoradiotherapy with concurrent gemcitabine and cisplatin with or without sequential chemotherapy with gemcitabine/cisplatin vs chemoradiotherapy with concurrent 5-fluorouracil in patients with locally advanced pancreatic cancer – a multi-centre randomised phase II study

被引：0
作者：
R Wilkowski
S Boeck
S Ostermaier
R Sauer
M Herbst
R Fietkau
M Flentje
S Miethe
H D Boettcher
T Scholten
C J Bruns
H G Rau
A Hinke
V Heinemann
机构：
[1] Klinik Bad Trissl,Department for Radiotherapy and Radiooncology
[2] Klinikum Grosshadern,Department of Internal Medicine III
[3] Ludwig-Maximilians-University of Munich,Department of Radiotherapy
[4] University of Erlangen,Department of Radiotherapy
[5] University of Regensburg,Department of Radiotherapy
[6] University of Rostock,Department of Radiotherapy
[7] University of Würzburg,Department of Radiotherapy
[8] University of Leipzig,Department of Radiotherapy
[9] University of Frankfurt,Department of Internal Medicine
[10] Krankenhaus,Department of Surgery
[11] Klinikum Grosshadern,Department of Surgery
[12] Ludwig-Maximilians-University of Munich,undefined
[13] Klinikum Dachau,undefined
[14] WiSP Research Institute,undefined
来源：
British Journal of Cancer | 2009年 / 101卷
关键词：
chemoradiotherapy; cisplatin; gemcitabine; pancreatic cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1853 / 1859
页数：6
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共 291 条
[1]  
Burris HA(1997)Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 2403-2413
[2]  
Moore MJ(2008)Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000–01 FFCD/SFRO study Ann Oncol 19 1592-1599
[3]  
Andersen J(2006)Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer J Clin Oncol 24 1145-1151
[4]  
Green MR(2005)Phase III randomised comparison of gemcitabine (GEM) Eur J Cancer 3 4-4592
[5]  
Rothenberg ML(2007) gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer J Clin Oncol 25 4587-91
[6]  
Modiano MR(2008)Phase I study of oxaliplatin, full-dose gemcitabine, and concurrent radiation therapy in pancreatic cancer Ann Oncol 19 86-2572
[7]  
Cripps MC(2007)A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, non-operable pancreatic adenocarcinoma J Clin Oncol 25 2567-3952
[8]  
Portenoy RK(2006)Gemcitabine, cisplatin, and radiotherapy for patients with locally advanced pancreatic adenocarcinoma: results of the North Central Cancer Treatment Group phase II study N9942 J Clin Oncol 24 3946-2217
[9]  
Storniolo AM(2008)Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer BMC Cancer 8 82-685
[10]  
Tarassoff P(2007)Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer J Clin Oncol 25 2212-887
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