Complex roles of necroptosis in cancer程序性坏死在癌症中的复杂作用

被引：0
作者：
Fang Zhu
Wei Zhang
Tao Yang
Su-dan He
机构：
[1] Soochow University,Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection
[2] Soochow University,Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology
[3] Chinese Academy of Medical Sciences & Peking Union Medial College,Center of Systems Medicine, Institute of Basic Medical Sciences
[4] Suzhou Institute of Systems Medicine,undefined
来源：
Journal of Zhejiang University-SCIENCE B | 2019年 / 20卷
关键词：
Cell death; Necroptosis; Cancer; Mixed lineage kinase domain-like protein (MLKL); Receptor-interacting protein (RIP) kinase; 细胞死亡; 细胞程序性坏死; 癌症; 混合谱系激 酶域样蛋白 (MLKL); 受体相互作用蛋白 (RIP) 激酶; Q255;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed lineage kinase domain-like protein (MLKL). Because of membrane rupture, necroptotic cells release damage-associated molecular patterns (DAMPs) that evoke immune responses. Necroptosis is emerging as an important cellular response in the modulation of cancer initiation, progression, and metastasis. Necroptosis of cancer cells is considered to be an immunogenic cell death capable of activating anti-tumor immunity. Necroptosis also participates in the promotion of myeloid cell-induced adaptive immune suppression and thus contributes to oncogenesis. In addition, necroptosis of endothelial cells and tumor cells is conducive to tumor metastasis. In this review, we summarize the current knowledge of the complex role of necroptosis in cancer and discuss the potential of targeting necroptosis components for cancer therapies.
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页码：399 / 413
页数：14
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