New insights into the immunology and evolution of HIV

被引:0
作者
Justin STEBBING
Steve PATTERSON
Frances GOTCH
机构
[1] Faculty of Medicine,Department of Immunology, Division of Investigative Science
[2] Imperial College of Science,undefined
[3] Technology and Medicine,undefined
[4] The Chelsea and Westminster Hospital,undefined
来源
Cell Research | 2003年 / 13卷
关键词
HIV; immune response; CTL; evolution; vaccine;
D O I
暂无
中图分类号
学科分类号
摘要
Fewer than one million HIV infected individuals are currently receiving anti-retroviral therapy. The limitations of such treatment have underscored the need to develop more effective strategies to control the spread and pathogenesis of HIV. Typically, naturally occurring protective immune responses provide the paradigm for such development. It is now clear however that HIV can utilise the millieu of an activated immune system to its own replicative advantage. Mobilisation of the immune response, intended to thwart the virus, may instead fuel its dissemination, immune escape and spread. The immense genetic variation of HIV contributes to lack of immune control and the development of progressive disease in the majority of infected, untreated individuals. Further delineation of the intimate interactions between the HIV and the immune system will be critical and recent advances in this direction are discussed.
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页码:1 / 7
页数:6
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