In Vitro Antiviral Activity of Two Host Defense Peptides Against Human alphaherpesvirus 1

被引：0
作者：
Gisele Regina Rodrigues
Rhayfa Lorrayne Araujo Berlanda
Liana Costa Pereira Vilas Boas
Lídia Maria Pinto de Lima
Octávio Luiz Franco
机构：
[1] Pós-Graduação Em Ciências Genômicas E Biotecnologia,Centro de Análises Proteômicas E Bioquímicas
[2] Universidade Católica de Brasília,undefined
[3] Universidade de Brasília,undefined
[4] Pós-Graduação Em Patologia Molecular,undefined
[5] S-Inova Biotech,undefined
[6] Pós-Graduação Em Biotecnologia Universidade Católica Dom Bosco,undefined
来源：
International Journal of Peptide Research and Therapeutics | / 30卷
关键词：
Viral infections; Antiviral; Host defense peptides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Viral infections are continually emerging with new characteristics and the potential to cause outbreaks or pandemics. Therefore, identification of new antiviral compounds is extremely necessary for therapeutic. This study aimed to evaluate the in vitro action of host defense peptides against Human alphaherpesvirus 1 (HHV-1) replication. Vero cell monolayers were infected with HHV-1 TCID50 and treated with different concentrations of IDR-1018 and DJK-6. The cell viability was evaluated by MTT method. Time of addition assays were performed to infer the effect of peptides upon the viral replicative cycle. IDR-1018 and DJK-6 were able to inhibit the HHV-1 replication in maximum nontoxic concentrations. However, IDR-1018 presented higher potency and a better safety profile. In addition, IDR-1018 probably inhibits adhesion, entry and post entry of virus infection. DJK-6 seems to be capable of interfering with virus entry and viral biosynthesis.
引用
收藏
相关论文
共 349 条
  • [1] Acosta Davila JA(2019)An overview of peripheral blood mononuclear cells as a model for immunological research of Front Cell Infect Microbiol 9 24-16
  • [2] Hernandez De Los Rios A(2021) and other apicomplexan parasites Molecules 26 6994-459
  • [3] Ardebili A(2020)Antiviral therapeutic potential of curcumin: an update Protein Pept Lett 27 4-1443
  • [4] Pouriayevali MH(2005)Mini review on antimicrobial peptides, sources, mechanism and recent applications J Leukoc Biol 77 451-472
  • [5] Aleshikh S(2020)Impact of LL-37 on anti-infective immunity Curr Med Chem 27 1420-205
  • [6] Zahani M(2020)Antiviral activities of human host defense peptides J Clin Virol 125 469-520
  • [7] Ajorloo M(2007)Phenotypic testing of patient herpes simplex virus type 1 and 2 isolates for acyclovir resistance by a novel method based on real-time cell analysis Mem Inst Oswaldo Cruz 102 1314-860
  • [8] Izanloo A(2022)In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus iScience 25 196-9478
  • [9] Siyadatpanah A(2023)Antibacterial and anti-inflammatory properties of host defense peptides against Viruses 15 515-135
  • [10] Razavi Nikoo H(2015)A narrative review of alternative symptomatic treatments for herpes simplex virus Chem Biol 22 855-e2616
12345678910