Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring

被引：0

作者：

M. R. Alcorta-García

C. N. López-Villaseñor

G. Sánchez-Ferrer

H. Flores-Mendoza

F. Castorena-Torres

M. A. Aguilar-Torres

C. M. Sepúlveda-Treviño

J. A. Hernández-Hernández

R. C. López-Sánchez

V. J. Lara-Díaz

机构：

[1] Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenida Ignacio Morones Prieto 3000 poniente, Colonia Doctores, Monterrey, CP 64710, Nuevo León

[2] Hospital Regional Materno Infantil, Secretaria de Salud, Gobierno del Estado de Nuevo León, Avenida San Rafael 450, Colonia San Rafael, Ciudad Guadalupe, CP 67140, Nuevo León

来源：

Molecular and Cellular Pediatrics | / 7卷 / 1期

关键词：

Caffeine; Cytochrome P-450 CYP1A2 inducers; Cytochrome P-450 CYP1A2 inhibitors; Cytochrome P-450 CYP2E1 inducers; Cytochrome P-450 CYP2E1 inhibitors; Cytochrome P-450 Enzyme System; Infant; Premature; Premature birth;

D O I：

10.1186/s40348-020-00096-3

中图分类号：

学科分类号：

摘要：

Background: To ascertain interactions of caffeine ingestion, food, medications, and environmental exposures during preterm human gestation, under informed consent, we studied a cohort of Mexican women with further preterm offspring born at ≤ 34 completed weeks. At birth, blood samples were taken from mothers and umbilical cords to determine caffeine and metabolites concentrations and CYP1A2 (rs762551) and CYP2E1 (rs2031920, rs3813867) polymorphisms involved in caffeine metabolism. Results: In 90 pregnant women who gave birth to 98 preterm neonates, self-informed caffeine ingestion rate was 97%, laboratory confirmed rate was 93 %. Theobromine was the predominant metabolite found. Consumption of acetaminophen correlated significantly with changes in caffeine metabolism (acetaminophen R2 = 0.637, p = 0.01) due to activation of CYP2E1 alternate pathways. The main caffeine source was cola soft drinks. Conclusion: Environmental exposures, especially acetaminophen ingestion during human preterm pregnancy, can modulate CYP2E1 metabolic activity. © 2020, The Author(s).

引用

共 43 条

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