Determination of Binding Constants for Cyclodextrin Complexes with Alkanols by the 1H NMR Measurements of Longitudinal Relaxation Time Using Tetramethylammonium Chloride as an Internal Reference

被引：0
作者：
Jalaluddin Ahmed
Tatsuyuki Yamamoto
Yoshihisa Matsui
机构：
[1] Shimane University,Faculty of Life and Environmental Science
[2] Nishikawatsu,undefined
来源：
Journal of inclusion phenomena and macrocyclic chemistry | 2000年 / 38卷
关键词：
cyclodextrin; alkanol; inclusion complex; binding constant; NMR spectroscopy; longitudinal relaxation time; ROESY spectrum;
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摘要：
The longitudinal relaxation times (T1)of 1H NMR signals for a variety of alkanols in D2Omarkedly decreased with increasing concentrations (c)of α- and β-cyclodextrins (CD). Tetramethylammoniumchloride (TMA) used as an internal reference wasavailable for evaluating an effect of solutionviscosity on relaxation rates R(=1/T1), since TMAshowed no appreciable interaction with CD. Changes inthe ratio of R for alkanol protons to R for TMAprotons with c were analyzed by the curve-fittingmethod to give Ka. These Ka values agreedwell with those obtained by the analysis of changesin δ, indicating that T1 measurement is available forthe determination of Ka for CD complexes. 2D ROESYspectra provided definite information on the molecularstructures of CD complexes with alkanols.
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页码：267 / 276
页数：9
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