Synthesis, Anthelmintic, and Insecticidal Activity of 2-(3-Methyl-6-Methoxy-7-Ethoxy-3,4-Dihydroisoquinolyl-1)Ethanoic Acid Amides

被引：0

作者：

O. V. Surikova

A. G. Mikhailovskii

B. Ya. Syropyatov

M. I. Vakhrin

机构：

[1] Perm State Pharmaceutical Academy,

来源：

Pharmaceutical Chemistry Journal | 2015年 / 48卷

关键词：

2-(3-methyl-6-methoxy-7-ethoxy-3,4-dihydroisoquinolyl-1)ethanoic acid amides; anthelmintic and insecticidal activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of 2-(3-methyl-6-methoxy-7-ethoxy-3,4-dihydroisoquinolyl-1)ethanoic acid amides were synthesized via cyclocondensation of O-ethylated eugenol with cyanoacetic acid amides. Hydrochlorides of the synthesized compounds were shown to exhibit anthelmintic activity. The unsubstituted amide was the most active and exhibited activity equal to that of levamisole and significantly greater than that of pyrantel. The insecticidal activity of the synthesized compounds was inferior to that of imidacloprid.

引用

页码：665 / 668

页数：3

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