Mesenchymal Stem Cells and Periodontal Regeneration

被引：0
作者：
Hughes F.J. [1 ]
机构：
[1] Dental Institute, Kings College London, Floor 21 Tower Wing, Guys Hospital, London
来源：
Current Oral Health Reports | 2014年 / 1卷 / 1期
关键词：
Bone; Bone marrow; Cementum; Dental stem cells; Immunomodulation; Inducible pluripotent stem cells; Allogeneic; Mesenchymal stem cell; Periodontal; Periodontal ligament; Regeneration; Scaffolds; Tissue engineering;
D O I：
10.1007/s40496-013-0010-7
中图分类号：
学科分类号：
摘要：
The use of mesenchymal stem cell (MSC) therapy offers the potential to develop a completely novel and improved method of periodontal regeneration compared to existing methods. Since the initial demonstration of the presence of MSCs in the periodontal ligament, many recent studies have now demonstrated the potential for the transplantation of MSCs from PDL and other sources to enhance periodontal regenerative outcomes in a variety of animal models. In addition, the recent demonstration of the possible utility of allogeneic MSCs and MSCs derived from inducible pluripotent stem cells may offer new methods of delivering such therapies. Determination of the specific roles that MSCs may play in enhancing regenerative outcomes requires further investigation. The principle of MSC-directed periodontal regenerative therapy is accepted in the field, but extensive investigation is necessary to establish viable, efficacious, and practically applicable human therapies. © 2014, Springer International Publishing AG.
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页码：1 / 8
页数：7
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