Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans

被引：27
作者：
Chatterjee K. [1 ]
Engelmark M. [2 ]
Gyllensten U. [2 ]
Dandara C. [3 ]
Merwe L. [4 ,5 ]
Galal U. [4 ]
Hoffman M. [6 ]
Williamson A.-L. [1 ]
机构：
[1] Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine (IIDMM), University of Cape Town, Cape Town
[2] Departments of Genetics and Pathology, Uppsala University, Uppsala
[3] Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town
[4] Biostatistics Unit, Medical Research Council, Cape Town
[5] Department of Statistics, Faculty of Natural Sciences, University of Western Cape, Bellville
[6] School of Public Health and Family Medicine, University of Cape Town, Cape Town
来源：
BMC Research Notes | / 2卷 / 1期
基金：
新加坡国家研究基金会;
关键词：
Cervical Cancer; Invasive Cervical Cancer; South African Woman; Tight Linkage Disequilibrium; FasL Gene;
D O I：
10.1186/1756-0500-2-238
中图分类号：
学科分类号：
摘要：
Background. Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated whether these polymorphisms are associated with cervical cancer or human papillomavirus (HPV) infection in South African women. Findings. Participants were 447 women with invasive cervical cancer (106 black African and 341 women of mixed-ancestry) and 424 healthy women controls, matched by age, (101 black African and 323 women of mixed-ancestry) and domicile (rural or urban). Two polymorphisms in Fas gene (FasR-1377G/A, FasR-670A/G) and one in FasL gene (FasL844T/C) were genotyped by TaqMan. None of the polymorphisms, or the Fas haplotypes, showed a significant association with cervical cancer. There was also no association with HPV infection in the control group. However, on analysis of the control group, highly significant allele, genotype and haplotype differences were found between the two ethnic groups. There were generally low frequencies of FasR-1377A alleles, FasR-670A alleles and FasL-844C alleles in black women compared to the women of mixed-ancestry. Conclusion. This is the first study on the role of Fas and FasL polymorphisms in cervical cancer in African populations. Our results suggest that these SNPs are not associated with cervical cancer in these populations. The allele frequencies of the three SNPs differed markedly between the indigenous African black and mixed-ancestry populations. © 2009 Williamson et al; licensee BioMed Central Ltd.
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