Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines

被引：0

作者：

S. N. Sirakanyan

É. K. Akopyan

R. G. Paronikyan

I. M. Nazaryan

A. G. Akopyan

A. A. Ovakimyan

机构：

[1] A. I. Mnjoyan Institute of Fine Organic Chemistry,

[2] Scientific Technological Center of Organic and Pharmaceutical Chemistry,undefined

[3] National Academy of Sciences of Armenia,undefined

来源：

Pharmaceutical Chemistry Journal | 2019年 / 53卷

关键词：

disubstituted piperazine; alkylation; neurotropic activity; anxiolytic activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4-c]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.

引用

页码：495 / 499

页数：4