Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines

被引：0
作者：
S. N. Sirakanyan
É. K. Akopyan
R. G. Paronikyan
I. M. Nazaryan
A. G. Akopyan
A. A. Ovakimyan
机构：
[1] A. I. Mnjoyan Institute of Fine Organic Chemistry,
[2] Scientific Technological Center of Organic and Pharmaceutical Chemistry,undefined
[3] National Academy of Sciences of Armenia,undefined
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
disubstituted piperazine; alkylation; neurotropic activity; anxiolytic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4-c]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.
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页码：495 / 499
页数：4
相关论文
共 22 条
[1]  
Gillet R(1998)undefined Cancer Chemother. Pharmacol. 41 252-255
[2]  
Jeannesson P(1999)undefined Tetrahedron Lett. 40 5295-5299
[3]  
Sefraoui H(2004)undefined Bioorg. Med. Chem. 12 2225-2238
[4]  
Hulme C(2013)undefined Mini-Rev. Med. Chem. 13 1579-1601
[5]  
Ma L(2006)undefined Bioorg. Med. Chem. 14 1819-1826
[6]  
Romano J(1990)undefined Arm. Khim. Zh. 43 518-523
[7]  
Morisette M(1957)undefined Pharm. Assoc. Sci. Ed. 46 208-209
[8]  
Upadhayaya RS(2001)undefined Behav. Brain Res. 125 151-157
[9]  
Sinha N(undefined)undefined undefined undefined undefined-undefined
[10]  
Jain S(undefined)undefined undefined undefined undefined-undefined
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