Design, solvent-free synthesis and antibacterial activity evaluation of new coumarin sulfonamides

被引：0
作者：
Farzaneh Aminarshad
Shima Heidari
Neda Mostajeran
Ahmad Reza Massah
机构：
[1] Islamic Azad University,Department of Chemistry, Shahreza Branch
[2] Mashhad University of Medical Sciences,Department of Pharmaceutical Nanotechnology, School of Pharmacy
[3] Mashhad University of Medical Sciences,Nanotechnology Research Center, Pharmaceutical Technology Institute
[4] Islamic Azad University Shahreza Branch,Razi Chemistry Research Center
来源：
Journal of the Iranian Chemical Society | 2022年 / 19卷
关键词：
Coumarin; Sulfonamide; Solvent-free; Antibacterial;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A simple cost-effective and green method was presented for the synthesis of coumarin bis sulfonamides. Seventeen novel coumarin sulfonamides were synthesized in good to high yield and purity in six steps starting from 2-amino thiazole, aniline, and 4-methoxy aniline. All of the reactions have been done under green conditions without using any hazardous solvent. The chemical structures of the products were elucidated by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. Also, the anti-bacterial properties of the synthesized sulfonamides were investigated using two strains of Staphylococcus (gram-positive) and Escherichia coli (gram-negative) bacteria.
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页码：547 / 562
页数：15
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