Non-homologous end-joining, a sticky affair

被引：0
作者：
D C van Gent
M van der Burg
机构：
[1] Erasmus MC,Department of Cell Biology and Genetics
[2] University Medical Center Rotterdam,Department of Immunology
[3] Erasmus MC,undefined
[4] University Medical Center Rotterdam,undefined
来源：
Oncogene | 2007年 / 26卷
关键词：
DNA repair; V(D)J recombination; DNA double-strand break repair; severe combined immunodeficiency; DNA damage response; chromosomal instability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Rejoining of broken chromosomes is crucial for cell survival and prevention of malignant transformation. Most mammalian cells rely primarily on the non-homologous end-joining pathway of DNA double-strand break (DSB) repair to accomplish this task. This review focuses both on the core non-homologous end-joining machinery, which consists of DNA-dependent protein kinase and the ligase IV/XRCC4 complex, and on accessory factors that facilitate rejoining of a subset of the DSBs. We discuss how the ATM protein kinase and the Mre11/Rad50/Nbs1 complex might function in DSB repair and what role ionizing radiation-induced foci may play in this process.
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页码：7731 / 7740
页数：9
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  • [1] Ahnesorg P(2006)XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining Cell 124 301-313
  • [2] Smith P(2000)SAP—a putative DNA-binding motif involved in chromosomal organization Trends Biochem Sci 25 112-114
  • [3] Jackson SP(1999)DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes Proc Natl Acad Sci USA 96 14899-14904
  • [4] Aravind L(1998)Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice Curr Biol 8 1395-1398
  • [5] Koonin EV(2007)DNA damage checkpoints: from initiation to recovery or adaptation Curr Opin Cell Biol 19 238-245
  • [6] Bailey SM(2004)Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends Nucleic Acids Res 32 4351-4357
  • [7] Meyne J(1999)Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4 Mutat Res 433 53-58
  • [8] Chen DJ(2006)Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly Cell 124 287-299
  • [9] Kurimasa A(2006)Role of non-homologous end joining (NHEJ) in maintaining genomic integrity DNA Repair (Amst) 5 1042-1048
  • [10] Li GC(2006)The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells Nucleic Acids Res 34 2998-3007
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