Recruitment in AIDS clinical trials: Investigation of sociodemographic and psychosocial factors affecting participation in clinical research

被引：0
作者：
Ethier K.A. [1 ,4 ]
Rodriguez M.R. [2 ]
Fox-Tierney R.A. [1 ]
Martin C. [2 ]
Friedland G. [3 ]
Ickovics J.R. [1 ,2 ]
机构：
[1] Dept. of Epidemiol. and Pub. Health, Yale University, School of Medicine, New Haven, CT
[2] Department of Psychology, Yale University, New Haven, CT
[3] Department of Internal Medicine, Yale University, School of Medicine, New Haven, CT
[4] Yale University, New Haven, CT 06510-2483
来源：
AIDS and Behavior | 1999年 / 3卷 / 3期
基金：
美国国家卫生研究院;
关键词：
AIDS clinical trials; Attitudes; Injection drug users; Minorities; Psychosocial; Recruitment; Underrepresented populations; Women;
D O I：
10.1023/A:1025456527845
中图分类号：
学科分类号：
摘要：
The primary objective of this study was to identify the social, psychological, and behavioral factors that influenced recruitment in AIDS clinical trials. The study compared HIV-infected individuals participating in a trial (n = 113) and a group of HIV-infected patients not currently participating in a trial (n = 103). Trial participants were more likely to be White (61.5% vs. 38.8%, p < .004), MSM (40.7% vs. 20.4%, p < .0001), with no IDU history (74.0% vs. 38.8%, p < .0001). Among trial nonparticipants, 42.2% indicated willingness to participate in a trial. Gender, race, and IDU history was not related to willingness to participate in a trial. Trial nonparticipants rated almost all aspects of the trial regimen as significantly more difficult compared to trial participants. Trial participants differed significantly on sociodemographic dimensions and in beliefs and attitudes toward medical therapies. These differences may limit the generalizability of trial results and, consequently, the effectiveness of HIV therapeutics.
引用
收藏
页码：219 / 230
页数：11
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