Migraine and Epilepsy: A Focus on Overlapping Clinical, Pathophysiological, Molecular, and Therapeutic Aspects

被引：0
作者：
Marino Muxfeldt Bianchin
Renata Gomes Londero
José Eduardo Lima
Marcelo Eduardo Bigal
机构：
[1] Universidade Federal do Rio Grande do Sul,Division of Neurology, Hospital de Clínicas de Porto Alegre
[2] Universidade Federal do Rio Grande do Sul,Medical Science Postgraduate Program
[3] Universidade Federal de São Carlos,Department of Medicine, School of Medicine
[4] Global Director of Scientific Affairs: Neurology and Psychiatry,Department of Neurology
[5] Merck Research Laboratories,undefined
[6] Albert Einstein College of Medicine,undefined
来源：
Current Pain and Headache Reports | 2010年 / 14卷
关键词：
Comorbidity; Headache; Migraine; Epilepsy; Paroxysmal disorders;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The association of epilepsy and migraine has been long recognized. Migraine and epilepsy are both chronic disorders with episodic attacks. Furthermore, headache may be a premonitory or postdromic symptom of seizures, and migraine headaches may cause seizures per se (migralepsy). Migraine and epilepsy are comorbid, sharing pathophysiological mechanisms and common clinical features. Several recent studies identified common genetic and molecular substrates for migraine and epilepsy, including phenotypic-genotypic correlations with mutations in the CACNA1A, ATP1A2, and SCN1A genes, as well as in syndromes due to mutations in the SLC1A3, POLG, and C10orF2 genes. Herein, we review the relationship between migraine and epilepsy, focusing on clinical aspects and some recent pathophysiological and molecular studies.
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页码：276 / 283
页数：7
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