Frequency of fragmented QRS in ankylosing spondylitis: A prospective controlled study [Häufigkeit fragmentierter QRS-Komplexe bei Patienten mit ankylosierender Spondylitis: Eine prospektive, kontrollierte Studie]

被引：0
作者：
Inanir A. [1 ]
Ceyhan K. [2 ]
Okan S. [1 ]
Kadi H. [2 ]
机构：
[1] Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Gaziosmanpasa University
[2] Faculty of Medicine, Department of Cardiology, Gaziosmanpasa University, Tokat
来源：
Zeitschrift für Rheumatologie | 2013年 / 72卷 / 5期
关键词：
Ankylosing spondylitis; ECG; Fragmented QRS complex; Myocardial fibrosis; Predictive marker;
D O I：
10.1007/s00393-012-1102-9
中图分类号：
学科分类号：
摘要：
Objectives: Since inflammatory diseases may also cause fibrosis, we hypothesized that patients with ankylosing spondylitis (AS) may have frequent fragmented QRS complexes (fQRS) when compared to a control group. Patients and methods: In this prospective study, 71 patients with AS (group 1) were compared with 42 age- and gender-matched individuals without rheumatic disease (group 2, control). fQRS was described as the presence of an additional R wave (R') or R or S wave bridging, or the presence of fragmentation on two consecutive derivations that correspond to the major coronary artery regions. Results: The mean ages of groups 1 and 2 were 37.67 ± 9.17 and 40.43 ± 11.09 years, respectively (p = 0.270). fQRS was detected in 23 AS patients (32.4%), whereas 3 patients in the control group had fQRS (7.14%). Age, gender, medication, and echocardiography results were comparable. The disease duration score was 101.37 ± 59.96 months in fQRS(+) patients; in contrast, it was 57.93 ± 30.95 months in fQRS(-) patients. This difference was of statistical significance (p = 0.046). A statistically significant difference was not determined between the fQRS(+) and fQRS(-) groups when evaluated in terms of HLAB27 (p = 0.739). In the fQRS(+) group, the mean lumbar Schober score was 2.91 ± 1.52; in patients without fQRS, it was 4.10 ± 1.40. The mean thoracic expansion test scores in the fQRS(+) and fQRS(-) groups were 1.44 ± 0.66 and 2.69 ± 1.22, respectively. Conclusion: Given the higher frequency of fQRS detected in electrocardiography studies in AS patients than in the control group, cardiac fibrosis is thought to be more likely to occur in AS patients without cardiovascular disease. The presence of fQRS may be a simple and cost-effective method for predicting cardiac fibrosis in AS patients. fQRS can be a predictive marker for fibrosis in patients with AS. © 2012 Springer-Verlag Berlin Heidelberg.
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页码：468 / 473
页数：5
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  • [51] Bal, A., Unlu, E., Bahar, G., Comparison of serum IL-1β, sIL-2R, IL-6, and TNF-α levels with disease activity parameters in ankylosing spondylitis (2007) Clin Rheumatol, 26, pp. 211-215
  • [52] Grom, A.A., Murray, K.J., Luyrink, L., Patterns of expression of tumor necrosis factor α, tumor necrosis factor β, and their receptors in synovia of patients with juvenile rheumatoid arthritis and juvenile spondylarthropathy (1996) Arthritis Rheum, 39, pp. 1703-1710
  • [53] Braun, J., Brandt, J., Listing, J., Treatment of active ankylosing spondylitis with infliximab: A randomised controlled multicentre trial (2002) Lancet, 359, pp. 1187-1193
  • [54] Sun, M., Chen, M., Dawood, F., Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state (2007) Circulation, 115, pp. 1398-1407
  • [55] Braun, J., Berg, R., Van Den Baraliakos, X., 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis (2011) Ann Rheum Dis, 70, pp. 896-904
  • [56] Kadi, H., Inanir, A., Habiboglu, A., Frequency of fragmented QRS on ECG is increased in patients with rheumatoid arthritis without cardiovascular disease: A pilot study (2012) Mod Rheumatol, 22, pp. 238-242
  • [57] Viitanen, J.V., Kokko, M.L., Lehtinen, K., Correlation between mobility restrictions and radiologic changes in ankylosing spondylitis (1995) Spine, 20, pp. 492-496
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