High-performance thin-layer chromatographic method for the determination of chlorpyrifos and its metabolite in visceral samples

被引：0
作者：
Deepti Deshpande
Dinesh Gadmale
Suhas Bakre
Ashwini Kumar Srivastava
机构：
[1] University of Mumbai,Department of Chemistry
[2] Directorate of Forensic Science Laboratories,Toxicology Division
来源：
JPC – Journal of Planar Chromatography – Modern TLC | 2016年 / 29卷
关键词：
High-performance thin-layer chromatography; Chlorpyrifos; Metabolite; 3,5,6-Trichloropyridinol; Poisoning;
D O I：
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中图分类号：
学科分类号：
摘要：
In an attempt to determine chlorpyrifos insecticide and its metabolite 3,5,6-trichloropyridinol in visceral samples, a rapid high-performance thin-layer chromatographic method with densitometry is described. The recovery of chlorpyrifos from visceral tissues averaged 88%, while that of 3,5,6-trichlorpyridinol averaged 90%. The sensitivity and precision of the method were found to be adequate for the analysis of chlorpyrifos and its metabolite in a complex matrix like post-mortem tissues in forensic toxicology. The developed method has the advantage of using the sample extracts for analysis without cleanup.
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页码：429 / 434
页数：5
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