Fatigue in Parkinson’s disease: report from a multidisciplinary symposium

被引：62

作者：

Friedman J.H. ^{[1
,2
]}

Beck J.C. ^{[3
]}

Chou K.L. ^{[4
,5
]}

Clark G. ^{[3
]}

Fagundes C.P. ^{[6
,7
]}

Goetz C.G. ^{[8
]}

Herlofson K. ^{[9
]}

Kluger B. ^{[10
]}

Krupp L.B. ^{[11
]}

Lang A.E. ^{[12
]}

Lou J.-S. ^{[13
]}

Marsh L. ^{[14
,15
]}

Newbould A. ^{[3
]}

Weintraub D. ^{[16
]}

机构：

[1] Movement Disorders Program, Butler Hospital, Province, RI

[2] Department of Neurology, Alpert Medical School of Brown University, Providence, RI

[3] Parkinson’s Disease Foundation, New York, NY

[4] Department of Neurology, University of Michigan Health System, Ann Arbor, MI

[5] Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI

[6] Department of Psychology, Rice University, M.D. Anderson Cancer Center, Houston, TX

[7] Department of Health Disparities, Houston, TX

[8] Department of Neurological Sciences, Rush University Medical Center, Chicago, IL

[9] Department of Neurology, Sorlandet Hospital, Arendal

[10] Department of Neurology, University of Colorado Anschutz Campus, Aurora, CO

[11] Department of Neurology, Stony Brook University Medical Center, Stony Brook, NY

[12] Toronto Western Hospital, Morton and Gloria Shulman Movement Disorders Clinic and Edmond J Safra Program in Parkinson’s Disease, Toronto, ON

[13] University of North Dakota School of Medicine and Health Services, Sanford Health, Grand Forks, ND

[14] Department of Psychiatry, Baylor College of Medicine, Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX

[15] Department of Neurology, Baylor College of Medicine, Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX

[16] Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

来源：

npj Parkinson's Disease | / 2卷 / 1期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/npjparkd.2015.25

中图分类号：

学科分类号：

摘要：

Fatigue is a severe problem for many people living with Parkinson’s disease (PD). Best estimates suggest that more than 50% of patients experience this debilitating symptom. Little is known about its etiology or treatment, making the understanding of fatigue a true unmet need. As part of the Parkinson’s Disease Foundation Community Choice Research Program, patients, caregivers, and scientists attended a symposium on fatigue on 16 and 17 October 2014. We present a summary of that meeting, reviewing what is known about the diagnosis and treatment of fatigue, its physiology, and what we might learn from multiple sclerosis (MS), depression, and cancer—disorders in which fatigue figures prominently too. We conclude with focused recommendations to enhance our understanding and treatment of this prominent problem in PD. © 2016, The Author(s).

引用

共 67 条

[41]

Krupp L.B., Serafin D.J., Christodoulou C., Multiple sclerosis associated fatigue, Exp. Rev. Neurother., 10, pp. 1437-1447, (2010)

[42]

Robinson R.L., Et al., The importance of unresolved Fatigue in Depression: Costs and Comorbidities, Psychosom, 56, pp. 274-285, (2015)

[43]

Nierenberg A.A., Et al., Residual symptoms after remission in major depressive disorder with citalopram and risk of relapse: a STAR*D report, Psychol. Med., 40, pp. 41-50, (2010)

[44]

Fava M., Et al., A cross sectional study of the prevalence of cognitive and physical symptoms during long term antidepressant treatment, J. Clin. Psychiatr, 67, pp. 1754-1759, (2006)

[45]

Friedman J.H., Et al., Fatigue rating scales critique and recommendations by the Movement Disorders Society task force on rating scales for Parkinson’s disease, Mov. Disord., 25, pp. 805-822, (2010)

[46]

Krupp L.B., LaRocca N.G., Muir-Nash J., Steinberg A.D., The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus, Arch. Neurol., 46, pp. 1121-1123, (1989)

[47]

Cella D., Et al., Validation of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Scale relative to other instrumentation in patients with rheumatoid arthritis, J. Rhematol., 32, pp. 811-819, (2005)

[48]

Schiehser D.M., Et al., Validation of the Modified Fatigue Impact Scale in Parkinson's disease, Parkinsonism Relat. Disord., 19, pp. 335-338, (2013)

[49]

Lou J.S., Et al., Levodopa improves physical fatigue in Parkinson's disease: a double-blind, placebo-controlled, crossover study, Mov. Disord., 18, pp. 1108-1114, (2003)

[50]

Kluger B.M., Krupp L.B., Enoka R.M., Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy, Neurology, 80, pp. 409-416, (2013)

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