Positron Emission Tomography Imaging of Small Animals in Anticancer Drug Development

被引：0
|
作者：
Eric O. Aboagye
机构：
[1] Imperial College London,Molecular Therapy and PET Oncology Research group, The Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital Campus
来源：
Molecular Imaging and Biology | 2005年 / 7卷
关键词：
Small animal imaging; PET; Anticancer; Drug development;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Positron emission tomography (PET) imaging of small animals enables researchers to bridge the gap between in vitro science and in vivo human studies. The imaging paradigm can be established and refined in animals before implementation in humans and image data related to ex vivo assays of biological activity. Small animal PET (saPET) imaging enables assessment of baseline focal pathophysiology, pharmacokinetics, biological target modulation and the efficacy of novel drugs. The potential and challenge of this technology as applied to anticancer drug development is discussed here.
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页码：53 / 58
页数：5
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