Adult stem cells and their trans-differentiation potential—perspectives and therapeutic applications

被引：0

作者：

Sabine Hombach-Klonisch

Soumya Panigrahi

Iran Rashedi

Anja Seifert

Esteban Alberti

Paola Pocar

Maciej Kurpisz

Klaus Schulze-Osthoff

Andrzej Mackiewicz

Marek Los

机构：

[1] University of Manitoba,Department of Human Anatomy and Cell Science

[2] University of Manitoba,Department of Physiology

[3] University of Manitoba,Manitoba Institute of Cell Biology, CancerCare Manitoba

[4] University of Manitoba,Department of Biochemistry and Medical Genetics

[5] CIREN,Department of Neurobiology, International Center of Neurological Restoration

[6] University of Milan,Department of Animal Science, Faculty of Veterinary Medicine

[7] Polish Academy of Science,Institute of Human Genetics

[8] University of Duesseldorf,Institute of Molecular Medicine

[9] Poznan University of Medical Sciences,Department of Cancer Immunology

[10] and Great-Poland Cancer Center,undefined

[11] BioApplications Enterprises,undefined

来源：

Journal of Molecular Medicine | 2008年 / 86卷

关键词：

Autoimmune disease; G-CSF; Graft vs. host reaction; Stem/progenitor cell; Trans-differentiation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Stem cells are self-renewing multipotent progenitors with the broadest developmental potential in a given tissue at a given time. Normal stem cells in the adult organism are responsible for renewal and repair of aged or damaged tissue. Adult stem cells are present in virtually all tissues and during most stages of development. In this review, we introduce the reader to the basic information about the field. We describe selected stem cell isolation techniques and stem cell markers for various stem cell populations. These include makers for endothelial progenitor cells (CD146/MCAM/MUC18/S-endo-1, CD34, CD133/prominin, Tie-2, Flk1/KD/VEGFR2), hematopoietic stem cells (CD34, CD117/c-Kit, Sca1), mesenchymal stem cells (CD146/MCAM/MUC18/S-endo-1, STRO-1, Thy-1), neural stem cells (CD133/prominin, nestin, NCAM), mammary stem cells (CD24, CD29, Sca1), and intestinal stem cells (NCAM, CD34, Thy-1, CD117/c-Kit, Flt-3). Separate section provides a concise summary of recent clinical trials involving stem cells directed towards improvement of a damaged myocardium. In the last part of the review, we reflect on the field and on future developments.

引用

页码：1301 / 1314

页数：13

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