Isolation and pharmacological activities of bromophenols fromRhodomela confervoides

被引：0

作者：

Han Lijun

Xu Nianjun

Shi Jiangong

Yan Xiaojun

Zheng Chengkui

机构：

[1] Chinese Academy of Sciences,Institute of Oceanology

[2] Chinese Academy of Medical Sciences,Institute of Marina Medica

[3] Ningbo University,Key Laboratory of Marine Biotechnology

来源：

Chinese Journal of Oceanology and Limnology | 2005年 / 23卷 / 2期

关键词：

bromophenol; antitumor; antibacterial;

D O I：

10.1007/BF02894243

中图分类号：

学科分类号：

摘要：

Four bromophenols were isolated from the extract of marine red alga,Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods inclding IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) bis (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4) 3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities againstStaphylococcus aurens andPseudomonas aeruginosa.

引用

页码：226 / 229

页数：3

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