A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

被引：0
作者：
Yin C Lin
Suchit Jhunjhunwala
Christopher Benner
Sven Heinz
Eva Welinder
Robert Mansson
Mikael Sigvardsson
James Hagman
Celso A Espinoza
Janusz Dutkowski
Trey Ideker
Christopher K Glass
Cornelis Murre
机构：
[1] University of California,Department of Molecular Biology
[2] San Diego,Department of Cellular and Molecular Medicine
[3] University of California,Department for Biomedicine and Surgery
[4] San Diego,Integrated Department of Immunology
[5] Center for Stem Cell Biology and Cell Therapy,Department of Bioengineering and Department of Cellular and Molecular Medicine
[6] Lund University,undefined
[7] Lund,undefined
[8] Linkoping University,undefined
[9] Linkoping,undefined
[10] National Jewish Health,undefined
[11] Ludwig Institute for Cancer Research,undefined
[12] University of California,undefined
[13] San Diego,undefined
[14] University of California,undefined
[15] San Diego,undefined
[16] The Institute for Genomic Medicine,undefined
[17] University of California,undefined
[18] San Diego,undefined
来源：
Nature Immunology | 2010年 / 11卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lineage specification and development require a hierarchy of transcription factors. Murre and colleagues have compiled a genome-wide set of cis-acting targets centered on E2A, EBF1 and Foxo1 that govern early B cell development.
引用
收藏
页码：635 / 643
页数：8
相关论文
共 89 条
  • [1] Cosgrove MS(2007)Histone proteomics and the epigenetic regulation of nucleosome mobility Expert Rev. Proteomics 4 465-478
  • [2] Ruthenburg AJ(2007)Multivalent engagement of chromatin modifications by linked binding modules Nat. Rev. Mol. Cell Biol. 8 983-994
  • [3] Li H(2005)Genome-wide map of nucleosome acetylation and methylation in yeast Cell 26 517-527
  • [4] Patel DJ(2007)Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome Nat. Genet. 39 311-318
  • [5] Allis CD(1998)Induction of EBF and multiple B lineage genes by the helix-loop-helix protein E12 J. Exp. Med. 188 699-713
  • [6] Pokholok DK(2004)Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent Immunity 20 349-360
  • [7] Heintzman ND(2009)Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development Genes Dev. 23 2376-2381
  • [8] Kee BL(2009)Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci J. Exp. Med. 206 2271-2284
  • [9] Murre C(2009)Stepwise activation of enhancer and promoter regions of the B cell commitment gene Immunity 30 508-520
  • [10] Ikawa T(2007) in early lymphopoiesis Mol. Cell. Biol. 2 579-594
123456789