Effect of drug resistance modulator, NO donor, on membrane structure and function of membrane-bound Ca2+-activated Mg2+-dependent ATPase

被引：0
|
作者：
T. A. Rajewskaya
S. A. Goncharova
N. P. Konovalova
R. A. Kotelnikova
L. V. Tatyanenko
机构：
[1] Russian Academy of Sciences,Institute for Problems of Chemical Physics
来源：
Bulletin of Experimental Biology and Medicine | 2008年 / 146卷
关键词：
drug resistance; nitric oxide donors; membrane structure; Ca; -ATPase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Exogenous NO donor 3,3-bis-(nitroxymethyl)oxetane (NMO) was synthesized at the Institute for Problems of Chemical Physics (Russian Academy of Sciences). This compound was shown to inhibit Ca2+-ATPase isolated from normal muscular cells and tumor cells. Both hydrolytic and transport functions of the enzyme were inhibited under these conditions. These changes were probably related to changes in membrane structure caused by NO donor. Our results suggest that changes in intracellular Ca2+ concentration can modulate the formation of tumor drug resistance.
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页码：200 / 202
页数：2
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