Frailty in Patients with Cardiovascular Disease: Why, When, and How to Measure

被引：156
作者：
Afilalo J. [1 ]
机构：
[1] Divisions of Cardiology and Clinical Epidemiology, Department of Medicine, SMBD-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2
来源：
Current Cardiovascular Risk Reports | 2011年 / 5卷 / 5期
关键词：
Aging; Cardiac surgery; Cardiovascular diseases; Frailty;
D O I：
10.1007/s12170-011-0186-0
中图分类号：
学科分类号：
摘要：
Frailty is a geriatric syndrome of impaired resistance to stressors due to a decline in physiologic reserve. Frailty and cardiovascular disease (CVD) share a common biological pathway, and CVD may accelerate the development of frailty. Frailty is identified in 25% to 50% of patients with CVD, depending on the frailty scale used and the population studied. Frail patients with CVD, especially those undergoing invasive procedures or suffering from coronary artery disease and heart failure, are more likely to suffer adverse outcomes as compared to their non-frail counterparts. Five-meter gait speed is a simple and effective way of objectively measuring frailty in patients with CVD and should be incorporated in risk assessment. © 2011 The Author(s).
引用
收藏
页码：467 / 472
页数：5
相关论文
共 65 条
[1]  
Bergman H., Ferrucci L., Guralnik J., Et al., Frailty: an emerging research and clinical paradigm-issues and controversies, J Gerontol A Biol Sci Med Sci, 62, pp. 731-737, (2007)
[2]  
American Heart Association
[3]  
Afilalo J., Karunananthan S., Eisenberg M.J., Alexander K.P., Bergman H., Role of frailty in patients with cardiovascular disease, Am J Cardiol, 103, pp. 1616-1621, (2009)
[4]  
De Martinis M., Franceschi C., Monti D., Ginaldi L., Inflammation markers predicting frailty and mortality in the elderly, Exp Mol Pathol, 80, pp. 219-227, (2006)
[5]  
Visser M., Pahor M., Taaffe D.R., Et al., Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study, J Gerontol A Biol Sci Med Sci, 57, (2002)
[6]  
Cesari M., Penninx B.W.J.H., Pahor M., Et al., Inflammatory markers and physical performance in older persons: the InCHIANTI study, J Gerontol A Biol Sci Med Sci, 59, pp. 242-248, (2004)
[7]  
Leng S.X., Xue Q.-L., Tian J., Huang Y., Yeh S.-H., Fried L.P., Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies I, Exp Gerontol, 44, pp. 511-516, (2009)
[8]  
Walston J., McBurnie M.A., Newman A., Et al., Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study, Arch Intern Med, 162, pp. 2333-2341, (2002)
[9]  
Hansson G.K., Inflammation, atherosclerosis, and coronary artery disease, N Engl J Med, 352, pp. 1685-1695, (2005)
[10]  
Chevalier S., Gougeon R., Nayar K., Morais J.A., Frailty amplifies the effects of aging on protein metabolism: role of protein intake, Am J Clin Nutr, 78, pp. 422-429, (2003)
1234567