Pure red cell aplasia associated with autoimmune hepatitis successfully treated with cyclosporine A

被引：1

作者：

Sato A. ^{[1
]}

Sano F. ^{[1
]}

Ishii T. ^{[1
]}

Adachi K. ^{[1
]}

Negishi R. ^{[1
]}

Matsumoto N. ^{[2
]}

Okuse C. ^{[2
]}

机构：

[1] Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Asahi-ku, Yokohama 241-0811

[2] Department of Internal Medicine, St. Marianna University School of Medicine, Miyamae-ku, Kawasaki 216-8511

来源：

Clinical Journal of Gastroenterology | 2014年 / 7卷 / 1期

关键词：

Autoimmune hepatitis; Cyclosporine; Pure red cell aplasia;

D O I：

10.1007/s12328-013-0448-0

中图分类号：

学科分类号：

摘要：

A 47-year-old female with a 17-year history of autoimmune hepatitis had been treated with prednisolone, azathioprine, and ursodeoxycholic acid. Although her alanine aminotransferase level occasionally showed mild abnormality, the prednisolone dose could not be increased because she had developed cataract during the course of her illness. In May 2012, she developed severe normochromic normocytic anemia without hemorrhage, and azathioprine was discontinued because it was suspected of being the cause. However, anemia recurred frequently even after discontinuation, necessitating repeated blood transfusions. Bone marrow analysis revealed selective erythroblastopenia, thus leading to a diagnosis of pure red cell aplasia. Cyclosporine A was administered, which led to a dramatic recovery from anemia, and stabilized her alanine aminotransferase levels. Furthermore, the prednisolone dose could be gradually tapered. Pure red cell aplasia associated with autoimmune hepatitis is extremely rare. The present case shows that patients with autoimmune hepatitis refractory to the standard treatment regimen and those with concomitant pure red cell aplasia may be treated with cyclosporine A. © The Author(s) 2014.

引用

页码：74 / 78

页数：4

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