Genetic Predispositions to Heart Failure

被引：0
作者：
Koh W. [1 ]
Wong C. [2 ]
Tang W.H.W. [3 ]
机构：
[1] Department of Pediatric Cardiology, Pediatrics Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, 44195, OH
[2] Center for Clinical Genomics, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, 44195, OH
[3] Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, 44195, OH
来源：
Current Cardiovascular Risk Reports | 2016年 / 10卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Cardiomyopathy; Channelopathy; Familial; Genetics; Genome-Wide Association Studies (GWAS); Heart failure;
D O I：
10.1007/s12170-016-0525-2
中图分类号：
学科分类号：
摘要：
Heart failure can be caused by either acquired or inherited cardiovascular diseases. With the rising incidence of heart failure (HF), there is a need to further understand the molecular pathogenesis of HF. There has been growing interest in the role of genetic predisposition for developing HF, not only in inherited cardiomyopathies but also in acquired cardiovascular diseases. There have been expanding knowledge bases in specific pathogenic variants of sarcomeric genes, as well as genes encoding structural and cytoskeleton proteins, ion channels, calcium cycling proteins, nuclear proteins or transcriptomic factors, and even mitochondrial genes. Beyond inherited cardiomyopathies, several genome-wide association studies have identified novel genes associated with HF, yet the pathophysiologic contributions and their propensities of therapeutic targeting remains unresolved. © 2016, Springer Science+Business Media New York.
引用
收藏
相关论文
共 78 条
  • [1] Bleumink G.S., Schut A.F., Sturkenboom M.C., Deckers J.W., van Duijn C.M., Stricker B.H., Genetic polymorphisms and heart failure, Genet Med, 6, 6, pp. 465-474, (2004)
  • [2] Yancy C.W., Jessup M., Bozkurt B., Et al., 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, J Am Coll Cardiol, 62, 16, pp. e147-e239, (2013)
  • [3] Remme W.J., Swedberg K., Guidelines for the diagnosis and treatment of chronic heart failure, Eur Heart J, 22, 17, pp. 1527-1560, (2001)
  • [4] Go A.S., Mozaffarian D., Roger V.L., Et al., Heart disease and stroke statistics—2014 update: a report from the American Heart Association, Circulation, 129, 3, pp. e28-e292, (2014)
  • [5] Braunwald E., Research advances in heart failure: a compendium, Circ Res, 113, 6, pp. 633-645, (2013)
  • [6] Dorn G.W., Genetics of common forms of heart failure, Curr Opin Cardiol, 26, 3, pp. 204-208, (2011)
  • [7] Creemers E.E., Wilde A.A., Pinto Y.M., Heart failure: advances through genomics, Nat Rev Genet, 12, 5, pp. 357-362, (2011)
  • [8] Maron B.J., Towbin J.A., Thiene G., Et al., Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee
  • [9] Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups
  • [10] and Council on Epidemiology and Prevention, Circulation, 113, 14, pp. 1807-1816, (2006)
12345678