Novel roles for GAPDH in cell death and carcinogenesis

被引：0
作者：
A Colell
D R Green
J-E Ricci
机构：
[1] Institut d’Investigacions Biomèdiques de Barcelona,Department of Cell Death and Proliferation
[2] Consejo Superior de Investigaciones Científicas and Liver Unit,Department of Immunology
[3] Hospital Clinic i Provincial,département d’Anesthésie Réanimation
[4] Centro de Investigaciones Biomédicas Esther Koplowitz,undefined
[5] and CIBEREHD,undefined
[6] IDIBAPS,undefined
[7] St. Jude Children’s Research Institute,undefined
[8] Inserm,undefined
[9] U895,undefined
[10] Centre Méditerranéen de Médecine Moléculaire (C3M),undefined
[11] équipe 3 AVENIR,undefined
[12] Nice,undefined
[13] F-06204 Cedex 3,undefined
[14] France,undefined
[15] Université de Nice-Sophia-Antipolis,undefined
[16] Faculté de Médecine,undefined
[17] Centre Hospitalier Universitaire de Nice,undefined
来源：
Cell Death & Differentiation | 2009年 / 16卷
关键词：
cell death; glycolysis; GAPDH; mitochondria; cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Growing evidence points to the fact that glucose metabolism has a central role in carcinogenesis. Among the enzymes controlling this energy production pathway, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is of particular interest. Initially identified as a glycolytic enzyme and considered as a housekeeping gene, this enzyme is actually tightly regulated and is involved in numerous cellular functions. Particularly intriguing are recent reports describing GAPDH as a regulator of cell death. However, its role in cell death is unclear; whereas some studies point toward a proapoptotic function, others describe a protective role and suggest its participation in tumor progression. In this study, we highlight recent findings and discuss potential mechanisms through which cells regulate GAPDH to fulfill its diverse functions to influence cell fate.
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页码：1573 / 1581
页数：8
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