Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

被引：0
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作者：
Randall J Bateman
Paul S Aisen
Bart De Strooper
Nick C Fox
Cynthia A Lemere
John M Ringman
Stephen Salloway
Reisa A Sperling
Manfred Windisch
Chengjie Xiong
机构：
[1] Washington University School of Medicine,Department of Neurology
[2] University of California San Diego,Department of Neurosciences
[3] Flanders Institute for Biotechnology (VIB),Department for Molecular and Developmental Genetics
[4] K.U. Leuven,Center for Human Genetics
[5] UCL Institute of Neurology,Dementia Research Centre
[6] University College London,Center for Neurologic Diseases
[7] Brigham and Women's Hospital,Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology
[8] Harvard Medical School,Department of Neurology, Memory and Aging Program
[9] David Geffen School of Medicine at UCLA,Department of Clinical Neurosciences and Psychiatry
[10] Butler Hospital,Center for Alzheimer Research and Treatment
[11] Brown Medical School,Division of Biostatistics
[12] Brigham and Women's Hospital,undefined
[13] Alzheimer's Disease Research Center,undefined
[14] Massachusetts General Hospital,undefined
[15] Harvard Medical School,undefined
[16] JSW LifeSciences GmbH,undefined
[17] Washington University,undefined
来源：
Alzheimer's Research & Therapy | / 3卷
关键词：
Mutation Carrier; Amyloid Precursor Protein; Cerebral Amyloid Angiopathy; Amyloid Precursor Protein Gene; Amyloid Positron Emission Tomography;
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摘要：
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.
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