Mechanisms of drug transfer across the human placenta.

被引：0
作者：
Eric M. van der Aa
Jenny H.J. Copius Peereboom-Stegeman
Jan Noordhoek
Frank W.J. Gribnau
Frans G.M. Russel
机构：
[1] University of Nijmegen,Departments of Pharmacology and Toxicology, Faculty of Medical Sciences
来源：
Pharmacy World and Science | 1998年 / 20卷
关键词：
Human placenta; Drug transfer; Drug transport; Pharmacokinetics; Placenta perfusion; Membrane vesicles; Cotyledon; Trophoblast; Cell culture;
D O I：
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学科分类号：
摘要：
In this review we summarized literature data on the mechanisms of human placental drug transport studied in the isolated perfused placental cotyledon, placental membrane vesicles or trophoblastic cell cultures. Overall human placental drug transport rarely exceeds the transfer of flow‐dependent and membrane‐limited marker compounds. Interestingly, relatively often placental drug transfer appeared to be much smaller, indicating impaired trans-placental transport, depending on the physico-chemical characteristics of the drug or placental factors such as tissue binding or metabolism. Although in perfusion studies overall human placental drug transport occurs by simple diffusion, at the membrane level several drug transport systems have been found, mainly for drugs structurally related to endogenous compounds.
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页码：139 / 148
页数：9
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