Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus

被引:0
作者
Mariano Malaguarnera
Ignazio Di Fazio
Maria Antonietta Romeo
Salvatore Restuccia
Antonina Laurino
Barbara Adriana Trovato
机构
[1] University of Catania,Department of Internal Medicine and Geriatrics
来源
Journal of Gastroenterology | 1997年 / 32卷
关键词
cytokines; interleukin 6 (IL-6); hepatitis C virus (HCV); chronic hepatitis; histological activity index (HAI);
D O I
暂无
中图分类号
学科分类号
摘要
Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and nonlymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients with chronic hepatitis C (divided into three groups depending on severity) and in 27 healthy controls. Our results showed a significant elevation (P<0.0001) in serum IL-6 levels in the patients with chronic hepatitis C, correlated with the histological activity index (HAI) and their HCV-RNA serum levels. This rise may represent the expression of the hepatitis C virusinduced inflammatory state.
引用
收藏
页码:211 / 215
页数:4
相关论文
共 59 条
[11]  
Brown TJ(1992)Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources J Gen Virol 73 673-679
[12]  
Shoyab M(1990)Surecut 0.6 mm liver biopsy in the diagnosis of cirrhosis Liver 10 217-220
[13]  
Schooltinink H(1994)Classification of chronic hepatitis: Diagnosis, grading and staging Hepatology 19 1513-1520
[14]  
Stoyan T(1993)Characterization of interleukin 1 and interleukin 6 production by hepatic endothelial cells and macrophages J Leuk Biol 53 126-132
[15]  
Roeb E(1992)Monokine gene expression in normal human liver: Selective involvment of the portal compartment Liver 12 34-41
[16]  
Malaguarnera M(1987)Interferon B 2/B cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factors and regulates the major acute phase protein response in liver cells Proc Natl Acad Sci USA 84 7251-7251
[17]  
Trovato BA(1991)Effects of cytokines on, the liver Hepatology 13 364-375
[18]  
Laurino A(1994)T cell-associated hepatic injury: Mediation by tumor necrosis factor and protection by interleukin 6 J Exp Med 179 1529-1537
[19]  
Malaguarnera M(1990)Interleukin 6 release by rat liver macrophages J Hepatol 11 376-373
[20]  
Di Fazio I(1992)Serum levels of cytokines in chronic liver disease Gastroenterology 103 264-274