Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus

被引：0
作者：
Mariano Malaguarnera
Ignazio Di Fazio
Maria Antonietta Romeo
Salvatore Restuccia
Antonina Laurino
Barbara Adriana Trovato
机构：
[1] University of Catania,Department of Internal Medicine and Geriatrics
来源：
Journal of Gastroenterology | 1997年 / 32卷
关键词：
cytokines; interleukin 6 (IL-6); hepatitis C virus (HCV); chronic hepatitis; histological activity index (HAI);
D O I：
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中图分类号：
学科分类号：
摘要：
Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and nonlymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients with chronic hepatitis C (divided into three groups depending on severity) and in 27 healthy controls. Our results showed a significant elevation (P<0.0001) in serum IL-6 levels in the patients with chronic hepatitis C, correlated with the histological activity index (HAI) and their HCV-RNA serum levels. This rise may represent the expression of the hepatitis C virusinduced inflammatory state.
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页码：211 / 215
页数：4
相关论文
共 59 条
[1]  
Bowcock AM(1988)The human “B2” interferon/hepatocyte stimulating factor/interleukin gene: DNA polymorphism studies and localization to chromosome 7p21 Genomics 3 8-12
[2]  
Kidd JR(1986)Human chromosome 7 carries the B2 interferon gene Proc Natl Acad Sci (USA) 83 5219-5222
[3]  
Lantrop M(1987)Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene EMBO J 6 2939-2945
[4]  
Sehgal PB(1992)Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro J Immunol 148 1731-1736
[5]  
Zilberstein A(1992)Ciliary neurotropic factor induces acute phase protein expression in hepatocytes FEBS letters 314 280-284
[6]  
Ruggieri RM(1996)Interleukin 6 in hepatitis C cirrhosis Panminerva Medica 48 207-211
[7]  
Yasukawa K(1996)Rôle de l' interleukine 6 dans le carcinome hépatocellulaire Bulletin du Cancer 83 379-384
[8]  
Hirano T(1993)Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy Gastroenterology 104 877-883
[9]  
Watanabe K(1993)Quantitation of hepatitis C virus RNA in serum of asymptomatic blood donors and patients with type C chronic liver disease Hepatology 17 545-550
[10]  
Richards CD(1989)Absolute mRNA quantification using the polymerase chain reaction (PCR): A novel approach by a PCR-aided transcript titration assay (PATTY) Nucleic Acids Res 17 9437-9446
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