Relaxin, Its Receptor (RXFP1), and Insulin-Like Peptide 4 Expression Through Gestation and in Placenta Accreta

被引：0
作者：
William Goh
Sandra Y. Yamamoto
Karen S. Thompson
Gillian D. Bryant-Greenwood
机构：
[1] John A. Burns School of Medicine,Department of Obstetrics, Gynecology and Women’s Health
[2] University of Hawaii,Department of Pathology
[3] John A. Burns School of Medicine,undefined
[4] University of Hawaii,undefined
来源：
Reproductive Sciences | 2013年 / 20卷
关键词：
placenta accreta; relaxin; RXFP1; INSL4; basal plate; trophoblast;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study was designed to show whether placental relaxin (RLN), its receptor (RXFP1), or insulin-like peptide 4 (INSL4) might have altered expression in patients with placenta accreta. The baseline expression of their genes through gestation (n = 34) was quantitated in the placental basal plate (BP) and villous trophoblast (TR), and compared to their expression in placenta accreta (n = 6). The proteins were also immunolocalized and quantitated in the accreta tissues. The messenger RNAs (mRNAs) of matrix metalloproteinase 9, -2, and tissue inhibitors of matrix metalloproteinase (TIMP)-1 were also measured. Results demonstrated that the BP and TR expressed low levels of RLN/RXFP1 and INSL4 through gestation. In accreta, increased RLN gene and protein in BP were associated with antepartum bleeding whereas INSL4 expression decreased throughout the TR. There were no changes in mRNAs for MMPs, but TIMP-1 was increased only in the invasive TR.
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页码：968 / 980
页数：12
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