Human follicular dendritic cells in vitro and follicular dendritic-cell-like cells

被引：0
作者：
Rikiya Tsunoda
Alain Bosseloir
Kikuo Onozaki
Ernst Heinen
Katsuya Miyake
Hiro-oki Okamura
Kazunori Suzuki
Teizou Fujita
Léon J. Simar
Naonori Sugai
机构：
[1] Department of Anatomy and Histology,
[2] Fukushima Medical College,undefined
[3] 1-Hikarigaoka,undefined
[4] Fukushima,undefined
[5] 960–12,undefined
[6] Japan,undefined
[7] Department of Human Histology,undefined
[8] University of Liège,undefined
[9] Liège,undefined
[10] Belgium,undefined
[11] Department of Chemical Hygiene and Nutrition,undefined
[12] Faculty of Pharmaceutical Sciences,undefined
[13] Nagoya City University,undefined
[14] Nagoya,undefined
[15] Japan,undefined
[16] Department of Biochemistry,undefined
[17] Fukushima Medical College,undefined
[18] Fukushima,undefined
[19] Japan,undefined
来源：
Cell and Tissue Research | 1997年 / 288卷
关键词：
Key words: Germinal center; Follicular dendritic cells; Cell culture; Adhesion and co-stimulatory molecules; Emperipolesis; Human;
D O I：
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中图分类号：
学科分类号：
摘要：
Human follicular dendritic cell (FDC)-like cells (FLC) have been utilized for the in vitro analysis of germinal center reactions. However, there is no consensus whether FLC represent FDC in vitro. The purpose of the present study has therefore been to determine distinguishing features of FDC and FLC in vitro. The expression of CD40, CD54, CD49d, cytokine (γ-IFN and IL-4)-dependent MHC-class II, and CD106 was observed to be specific for the determination of FDC in long-term culture. The cytokine-dependent emperipolesis of germinal center B cells was establised as another discriminating property for FDC in vitro. In 2 out of 72 long-term cultures of FDC, we encountered dividing cells among the non-dividing population of FDC. The dividing cells expressed accessory molecules similar to those of FDC but showed emperipolesis only for the initial few days of their growth. FDC did not enhance the CD40-dependent proliferation of germinal center B cells; in contrast, FLC augumented it. Both types of cells produced a significant amount of cytokine-dependent IL-6. Further studies are needed to determine whether FLC originate from FDC in vitro.
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页码：381 / 389
页数：8
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